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KMID : 0931320190190040225
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대한상부위장관.헬리코박터학회지
2019 Volume.19 No. 4 p.225 ~ p.230
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Eradication Therapy for Helicobacter pylori with Diagnostic Test for Clarithromycin Resistance
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Kim Yeon-Ji
Chung Woo-Chul
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Abstract
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Addressing the increasing antibiotic resistance, including clarithromycin resistance, which affects Helicobacter pylori (H. pylori) eradication therapy, is a challenge for clinicians. Antibiotic resistance is the main reason for H. pylori eradication failure and the resistance rate for clarithromycin may drastically increase, up to 38.5%, due to 23S ribosomal RNA point mutations. Therefore, the standard triple regimen is no longer suitable as the first-line treatment in most regions. However, there is a growing interest in personalized care for patients. Increased eradication rates of tailored therapy based on antibiotic susceptibility have been reported using nucleic acid-based techniques for clarithromycin resistance with a focus on the first-line eradication therapy of H. pylori infection. Herein, we discuss the eradication therapy for H. pylori, with a diagnostic test and appropriate treatment for clarithromycin resistance.
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KEYWORD
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Clarithromycin, Drug resistance, Eradication, Helicobacter pylori
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